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7. Nefarious from Ratchet & Clank

We love Clank as the loveable sidekick to Ratchet, but Dr. Nefarious is just the villain that this sci-fi series needed. Nefarious hates everything about organic life, even though he used to be organic himself. To satisfy his hatred, he spends most of the time concocting overly complicated plans to bring an end to life across the universe. Whether trying to transform every organism on every world into a robot, or changing time so the villains always win, Nefarious’ plots are too ridiculous to take seriously, and just the right challenge for the dynamic duo of Ratchet & Clank. A great villain can make a story, and Nefarious hits all the right notes to fit the franchise.